Tgm2 phosphorylation
Web20 Nov 2013 · In addition, HIF-1α downregulates oxidative phosphorylation by inactivating the major enzymes that regulate Krebs cycle, such as pyruvate dehydrogenase. ... of TG2 in drug-resistant breast tumors and tumor cell lines is mediated by aberrant epigenetic regulation of the TGM2 gene. 34 Moreover, ... Web2 Feb 2024 · The reduction in AKT phosphorylation, along with the increase in PARP1 cleavage, observed in both TGM2-v1-silenced cells and 1–155 treated cells under hypoxia, …
Tgm2 phosphorylation
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Web12 Feb 2016 · TGM2 inhibition potently sensitizes mTORC1-hyperactive cancer cells to rapamycin treatment, and a rapamycin-induced autophagy blockade inhibits the compensatory TGM2 upregulation. More importantly, tumor regression was observed in MCF-7-xenograft tumor-bearing mice treated with both mTORC1 and TGM2 inhibitors … WebKnockout of TFAP2A induced significant alterations in the transcriptome including repression of TGM2, identified as a primary gene target of AP-2alpha. Loss of AP-2alpha delayed progression through S-phase into G2/M and decreased phosphorylation of AKT, effects that were mediated through regulation of TGM2.
WebLung M2 macrophages are regulators of airway inflammation, associated with poor lung function in allergic asthma. Previously, we demonstrated that IL-4-induced M2 gene expression correlated with tyrosine phosphorylation of the insulin receptor substrate-2 (IRS-2) in macrophages. We hypothesized that negative regulation of IRS-2 activity after IL-4 … Web25 Feb 2013 · TGM2 is a stress-responsive gene that encodes a multifunctional and structurally complex protein called tissue transglutaminase (abbreviated as TG2 or tTG). ... Phosphorylation of transglutaminase 2 (TG2) at serine-216 plays a role in TG2 mediated activation of nuclear factor-kappa B and in the downregulation of PTEN. BMC Cancer. …
WebUsing peptide substrates and phosphospecific antibodies we demonstrated that TG2 phosphorylated Ser (10) in H3 and that this phosphorylation was reduced by acetylation, … Web5 Dec 2024 · TG2 promotes tumor cell proliferation and increases glycolysis associated with the activation of the MEK/ERK/LHD pathway. Peer Review reports Introduction Breast cancer (BC) is the most common malignant tumor among women worldwide and the second leading cause of cancer-related deaths [ 1 ].
Web25 Dec 2024 · However, oxidative phosphorylation-related signals (oxidative phosphorylation), extracellular matrix-related signals (epithelial-mesenchymal transition), and cell cycle-related signals (E2F targets) were significantly inhibited (Figure 5 and Table 1). The details of the genes involved in the top four enriched gene sets are shown in Table 1.
WebThe TGM2-positivity was determined using all fields of view (FOVs, 2.2-mm in diameter per FOV) containing HCC (15–107 FOVs per case) as follows: TGM2-positive HCC cells were … dshs monroe wa phone numberWeb21 Jul 2013 · Some more specific TGM2 inhibitors, such as ZM39923 and Tyrphostin 47, were discovered and may serve as valuable lead compounds for the development of orally active TGM2 inhibitors to treat human diseases. 44 In the present study, the finding that TGM2 regulated the cell proliferation of CD44-high glioma-initiating cells/CD44 + glioma … dshs montana food stampsWeb11 Jan 2024 · To further validate the function of Tgm2 in vivo, we generated Tgm2 knockout mice by CRISPR/Cas9 technology. 49 bp nucleotides were deleted in the exon 2 of Tgm2 … commercially important bamboo speciesWebHere, we demonstrate TG2 directly interacts with and facilitates the phosphorylation and activation of the integrin effector protein integrin-linked kinase (ILK) at Ser246. We show … commercially insolventWeb1 Dec 2024 · In order to explore the pathways by which Tgm2 regulates apoptosis, the expression levels of JNK1/2, ERK1/2, Akt, JAK2 and their phosphorylation levels were tested in Tgm2-knockdown RAW264.7 cells stimulated by LPS. commercially important fishWebTGM2 is a tumor and stem cell survival factor in breast and other cancers 43,44 . TGM2 has intrinsic and Ca 2+ dependent kinase activity and phosphorylates target proteins involved … dshs nar registrationWebTGM2 is a calcium-dependent enzyme that mediates cross-linking of ECM proteins, thus making ECM proteins resistant to enzymatic degradation and physical breakdown. We … commercially held student loans