Recombinant human il-1β
Webb5 nov. 2015 · Addition of recombinant human IL-1β monoclonal antibody or IL-1 receptor antagonist resulted in a dose- and time-dependent protection of cartilage from blood-induced damage. In higher concentrations, almost complete normalization of cartilage matrix proteoglycan turnover was achieved. WebbDetails. Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) …
Recombinant human il-1β
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WebbTarget Information. Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of ... WebbRecombinant human IL-1β is a 17.3 kDa protein containing 153 amino acid residues. The protein is manufactured without the use of any animal products/reagents and is …
WebbInterleukin-1β (IL1B) is produced by activated macrophages. It is synthesized as pro-IL-1β which is changed to active form IL-1β with the help of pro-inflammatory protease caspase-1. IL-1β belongs to the IL-1 gene family. It is a proinflammatory cytokine. The gene is mapped to human chromosome 2q14. WebbCellGenix® Recombinant Human IL-1β reliably stimulates the maturation of immature dendritic cells (DCs). It in addition promotes the generation of megakaryocytes derived from pluripotent stem cells (PSCs). CellGenix® rh IL-1β is produced in our dedicated animal-free GMP facility ensuring maximum safety for optimal use in ATMP …
Webb21 dec. 2024 · Objectives: To compare phagocytic activities of monocytes in peripheral blood mononuclear cells (PBMCs) from acute gout patients and normal subjects, examine monosodium urate monohydrate (MSU) crystal-induced IL-1β secretion ± recombinant human proteoglycan 4 (rhPRG4) or interleukin-1 receptor antagonist (IL-1RA), and study … WebbProduct Description. >98% as determined by SDS-PAGE of 6 μg reduced (+) and non-reduced (-) recombinant hIL-1β. All lots are greater than 98% pure. Less than 0.01 ng endotoxin/1 μg hIL-1β. The bioactivity of recombinant IL-1β was determined by its ability to induce IL-8 production by primary human fibroblasts.
WebbHuman IL-1β induces the proliferation of D10.G4.1 mouse helper lymphocytes in a dose-dependent manner. The ED 50 = 2.5 - 12.5 pg/mL. The specific activity of recombinant …
Webb12 apr. 2024 · Lymphocytes are often described as core cells in allergic diseases. As a lymphocyte stimulator, IL-1β can not only be secreted by B cells but also activate and strengthen the activity of B cells to a certain extent, thus promoting their differentiation into plasma cells and triggering the production of site-specific IgE [60, 61].As a cytophilic … syn for outlookWebbRecombinant human IL-1β is a 17.3kDa protein containing 153 amino acid residues. Application IL-1β (interleukin 1 β) human has been used to study the effect of pro- and … thai porcelain bowl textureIL-1β is a member of the interleukin 1 family of cytokines. This cytokine is produced by activated macrophages, monocytes, and a subset of dentritic cells known as slanDC, [13] as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). Visa mer Interleukin-1 beta (IL-1β) also known as leukocytic pyrogen, leukocytic endogenous mediator, mononuclear cell factor, lymphocyte activating factor and other names, is a cytokine protein that in humans is encoded … Visa mer The fever-producing property of human leukocytic pyrogen (interleukin 1) was purified by Dinarello in 1977 with a specific activity of 10–20 nanograms/kg. In 1979, Dinarello reported that purified human leukocytic pyrogen was the same molecule that was … Visa mer Anakinra is a recombinant and slightly modified version of the human interleukin 1 receptor antagonist protein. Anakinra blocks the biologic … Visa mer Because many authors of scientific manuscripts make the minor error of using a homoglyph, sharp s (ß), instead of beta (β), mentions of "IL-1ß" … Visa mer Before cleavage by caspase 1, pro-IL-1β has a molecular weight of 37 kDa. The molecular weight of the proteolytically processed IL-1β is … Visa mer Increased production of IL-1β causes a number of different autoinflammatory syndromes, most notably the monogenic conditions referred to as Cryopyrin-Associated Periodic Syndromes (CAPS), due to mutations in the inflammasome receptor NLRP3 … Visa mer • Smirnova MG, Kiselev SL, Gnuchev NV, Birchall JP, Pearson JP (2003). "Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion". European … Visa mer thai porcelain elephantWebbGeneral description IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if … syn for newsWebbIL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a … syn for painWebbRecombinant human IL-6 (Cat. No. 550071) is supplied as a frozen liquid comprised of 0.22 µm filtered aqueous buffered solution, glycerol and bovine serum albumin, with no … syn for outcomeWebbDescription: IL-1β is a proinflammatory cytokine produced in a variety of cells, including monocytes, tissue macrophages, keratinocytes, and other epithelial cells. Both IL-1α and … thai porcelain flower