WebJul 29, 2024 · It has been suggested that for every 10 cases of alanine aminotransferase (ALT) elevation (>10 times the upper limit of normal) in a clinical trial, there will be one case of more severe liver injury that develops once the drug is widely available [ 30,31 ]. WebJun 15, 2008 · Abstract. We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually …
Highly Sensitive Two-Photon Lipid Droplet Tracker for
WebPhospholipidosis is a lysosomal storage disorder characterized by excessive accumulation of intracellular phospholipids in tissues, such as the liver, kidney and lung. It is well … WebApr 27, 2009 · About 18 months after taking amiodarone, liver enzymes were noted to have increased and computed tomographic (CT) scanning of the abdomen showed a significant increase in the density of the liver without contrast medium, compared to that of the spleen and surrounding tissues (113 Hounsfield units (H), normal range of the liver is about … futsal field singapore
Phospholipidosis - Wikipedia
WebSep 1, 2013 · Ketoconazole was reported to cause phospholipidosis in the liver, lung and spleen (Whitehouse et al., 1994, Pakuts et al., 1990), but little is known about its effects on the kidneys in humans or animals. Thus, our findings about renal phospholipidosis are the first of their kind in ketoconazole-treated mice. WebPhospholipidosis and steatosis are two toxic effects, which course with overaccumulation of different classes of lipids in the liver. MS-based lipidomics has become a powerful tool … WebOct 1, 2014 · @article{osti_22439848, title = {Dysregulation of protein degradation pathways may mediate the liver injury and phospholipidosis associated with a cationic amphiphilic antibiotic drug}, author = {Mosedale, Merrie and Wu, Hong and Kurtz, C. Lisa and Schmidt, Stephen P. and Adkins, Karissa and Harrill, Alison H. and University of Arkansas for … futsal field diagram