Naphthoquinone hybrid as antimalarial
WitrynaIn this study, some novel 2-hydroxy-1,4-naphthoquinone-4-hydroxyaniline hybrid Mannich bases were designed, synthesized and eva luated for in vitro antimalarial … WitrynaThen, with the aim to kill multiresistant strains, we designed new hybrid antimalarial drugs with a dual mode of action, due to the presence within a single molecule of two pharmacophores that are not necessarily expected to act on the same biological …
Naphthoquinone hybrid as antimalarial
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WitrynaA new class of 1,4-naphthoquinone hybrids (37) which contain phenylamino-phenylthio moieties as significant counterparts demonstrated major antibacterial activity against bacterial strains Staphylococcus aureus, Listeria monocytogenes, E. coli, P. aeruginosa, Salmonella bongori and Klebsiella pneumoniae. 57–59) Two naphthoquinone … Witryna11 kwi 2024 · The concept of molecular hybridization has attracted much attention from medicinal chemists for the design and development of novel drug molecules [23].Creating hybrid molecules by fusing two physiologically active moieties has led to several exciting discoveries in medicinal chemistry [24].In this context 2,3-dihydro-1H-pyrazol-4 …
WitrynaThe naphthoquinone atovaquone, an analog of ubiquinone (coenzyme Q10), commonly used to treat pneumocystis pneumonia and malaria, inhibits complex III in cancer cell lines and breast cancer-stem-cells, by competitive inhibition of the active site of ubiquinone (Fiorillo et al., 2016 ). Atovaquone inhibits the ETC, decreases OxPhos, … Witryna20 paź 2015 · A novel series of 1,4-naphthoquinones (33-44) tethered by open and closed chain sulfonamide moieties were designed, synthesized and evaluated for their cytotoxic and antimalarial activities. All quinone-sulfonamide derivatives displayed a broad spectrum of cytotoxic activities against all of the tested cancer cell lines …
WitrynaIn this respect, lawsone derivatives, 3-(aminomethyl)-2-hydroxy-1,4-naphthoquinones 6, or amino naphthoquinone Mannich bases have been synthesized and evaluated as anticancer, antimalarial, antiviral, antifungal, and antibacterial molecules [19,20]; amino 7, and thioether 8 NQs , as well as the NQs with aromatic amines in carbon two or … WitrynaScientific Research Publishing
Witryna5 lis 2024 · Therefore, exploring antimalarial lead compounds with new categories is a significant priority. In 2015, Ratchanok Pingaew et al. [55] designed and synthesized a series of novel 1,4-naphthoquinone-based sulfonamides, in which restricted sulfonamide analog 85 (Fig. 15) containing. Other bioactivities involving quinone motif
Witrynalian host [8,9], and several antimalarial drugs show specificity for parasite CoQ, including the hydroxynaphthoquinones [10–12]. Atovaquone, an inhibitor of Complex III (or bc 1 … how to add to my host fileWitrynaRolf Müller, R. Müller, 2004, Journal of Cancer Research and Clinical Oncology. how to add to networkWitryna1 mar 2024 · A series of 3-substituted-2-hydroxy-1,4-naphthoquinone derivatives with a variety of side chains were successfully synthesized by Mannich reaction of 2-hydroxy-1,4-naphthoquinone (lawsone) with selected amines and aldehydes. All substances (1-16) were evaluated for in-vitro antimalarial activity aga … how to add to reading list edgeWitrynaAcequinocyl is a highly lipophilic naphthoquinone derivative. Similar compounds (2-alkyl-3-hydroxy-1,4-naphthoquinones) have been known for a considerable time to have a variety of pesticidal activities including antibacterial, acaricidal, antimalarial, fungicidal, and insecticidal actions (e.g., see Jacobsen and Pedersen, 1986). Acequinocyl ... how to add to safe senders list outlook 365Witryna10 lut 2024 · Recently, naphthoquinone derivatives have shown promising results as antiparasitic lead compounds [28].Conjugated hybrid compounds could be an effective path to discovery of new drugs by associating two different pharmacophore groups with different mechanisms of action in a single molecule [29, 30], which could yield a drug … how to add to your amazon wishlistWitryna1 cze 2024 · Lawsone, also known as hennotannic acid, is the natural pigment obtained from henna. Lawsone is chemically 2-hydroxy-1,4-naphthoquinone. The presence of the hydroxyl group is the major determinant ... how to add to sharepoint groupsWitryna1 lis 2024 · Molecular docking and molecular dynamics studies were also performed to evaluate the probable interactions between the hybrids and human ATP binding … how to add to list on amazon