Moa of cisplatin
WebCarboplatin is a second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich … WebHowever, cisplatin-based chemotherapy was associated with more severe nausea, vomiting, and nephrotoxicity while severe thrombocytopenia was more frequent during carboplatin-based chemotherapy. 36 Hence, the selection of the platinum compound should be made based on the regimen most likely to result in the best therapeutic index.
Moa of cisplatin
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Web5 okt. 2014 · Cisplatin has a molecular weight of 301.1 gm/mol, a density of 3.74 g/cm 3, a melting point of 270° C, a log K ow of -2.19 and a water solubility of 2.53 g/L at 25° C … Web17 feb. 2024 · Cisplatin can cause severe nausea and vomiting. Use highly effective antiemetic premedication. Nephrotoxicity: Cisplatin can cause severe renal toxicity, including acute renal failure. Severe renal toxicities …
Cisplatin is administered intravenously as short-term infusion in normal saline for treatment of solid and haematological malignancies. It is used to treat various types of cancers, including sarcomas, some carcinomas (e.g., small cell lung cancer, squamous cell carcinoma of the head and neck and ovarian cancer), lymphomas, bladder cancer, cervical cancer, and germ cell tumors. Because of its widespread use, the cure rate for testicular cancer has increased from 10% to 85… WebCisplatin - Uses, Dose, MOA, Brands, Side effects, Warnings Doctors Find Doctor by Speciality
WebCisplatin. Pt(NH3)2Cl2. Synonyms: cis -Diammineplatinum(II) dichloride, cis -Dichlorodiammine platinum(II), cis -Platinum(II) diammine dichloride, Cisplatin. CAS … Web24 mrt. 2015 · Statin 1. Statin: The Good, the Bad, and the Unknown DR. MOHAMMAD SAMIR AZAM SUNNY DEPARTMENT OF CARDIAC SURGERY, BSMMU 2. What is statin? Statins (or HMG-CoA reductase inhibitors) are a class of drugs used to lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase, which plays a central …
Web18 sep. 2024 · Cisplatin is a medication used to manage and treat solid tumors and hematologic malignancies. It is in the alkylating agent class …
WebIn the first quarter of 2024, the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) approved more than 25 new oncology agents and new … geoff backmanWebWe have simulated the permeation of cisplatin through a model membrane composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine lipids by means of umbrella sampling classical … geoff bainbridge first aid toowoombaWebCisplatin is in a class of drugs known as platinum-containing compounds used to treat various types of cancers including metastatic testicular and ovarian tu... chrisland cowgirlWebbifunctional alkylating agent; MOA unknown T/F chlorambucil has more grade 3/4 rxns than bendamustine F Nitrosoureas Carmustine, Lomustine, Streptozocin Formulation properties of Carmustine Lipid soluable compound administered in EtOh vehicle, burning at inj, potential to get drunk Time to nadir with carmustine 21-28 days; administer q6 weeks chrisland engineering lebanon paWebNephrotoxicity exacerbated by cisplatin is the chief dose-limiting factor in its clinical application in cancer chemotherapy (21). This process is manifested by destruction of … geoff badger edmontonWeb10 apr. 2024 · To figure out MOA of S. nigrum against breast cancer, we constructed the component-target-pathway network using the aforementioned information of active ... geoff bainbridgeWebCisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin … chris landers obituary