WebOct 29, 2014 · Carbonylation, Cyclization, Hydrocarbons, Phenyls Abstract The first nickel (0)-catalyzed [2 + 2 + 1] carbonylative cycloaddition reaction of imines and alkynes or norbornene has been achieved by employing phenyl formate as a CO source. WebThis book provides students and researchers in organic synthesis with a detailed discussion of carbonylation from the basics through to applications. The authors have structured the book around the types of reactions, based on the different nucleophiles involved.
ChemInform Abstract: Decarboxylative Alkynylation and Carbonylative …
To further showcase the synthetic potential for this nickel catalyzed carbonylative Negishi reaction using tert-butyl isocyanide as carbonyl source, the gram-scale synthesis of 4t was carried out with 90% isolated yield (Fig. 5a). The imine intermediate could be reduced using NaBH4 to provide the useful … See more We started our investigation by studying the nickel-catalyzed reaction of phenyl allyl acetate 1a and nC8H17ZnBr (1.5 equiv). To our delight, when the commercially available tert-butyl isocyanide (1.5 equiv) was used as the CO … See more With the optimized conditions in hand, we next explored the substrate scope of alkylated zinc nucleophiles (Fig. 2). The reaction tolerates a wide range of organozinc reagents, affording β,γ-unsaturated ketones … See more To shed light on the reaction mechanism, several experiments were performed (Fig. 6). When 1-phenylallyl acetate 1a′ was used as the allylic electrophile, the linear β,γ … See more The scope of allylic electrophiles was also investigated, the reaction proceeded well with both aryl and alkyl substituted alkene, affording the carbonylation product in 43–96% yield with excellent regio- and stereoselectivities … See more WebOct 1, 2024 · Carbonylative cyclization of alkene-tethered indole derivatives with alkyne-tethered nucleophiles. • Several pharmaceutical and bioactive molecule related compounds were also suitable substrates here. Download full-size image Keywords Palladium Catalyst Domino Reaction Carbonylation Cyclization Heterocycles how many days to spend in bucharest
Chemically circular, mechanically tough, and melt-processable ...
WebJan 29, 2024 · a, The modular process is capable of producing a diverse range of carbonyl-containing compounds. b, Chemodivergent carbonylation reactions using different acid chlorides or nucleophiles can... WebMar 17, 2024 · Carbonylative cross-couplings of organoaluminium with tert-butyl isocyanide as the CO source Indium has emerged as a useful metal in organic … WebApr 2, 2024 · A novel, selective and high-yielding palladium-catalyzed carbonylative arylation of a variety of weakly acidic (pKa 25–35 in DMSO) benzylic and heterobenzylic … high table with stool